Eight fire engines and around 60 firefighters tackled a fire on Crayford Way in Crayford.
Half of the ground floors of four terraced houses were damaged by fire and the the first floors and the roofs of the properties were destroyed by the blaze. A number of people left the buildings before the Brigade arrived. Crews cooled and removed two gas cylinders as a precaution as some cylinders can explode when exposed to heat.
Station Commander David Reed, who was at the scene, said: "The roof spanning across four terraced houses was completely alight.
"One of the Brigade's 32-metre turntable ladders was used as a water tower at the scene to get water on the building externally.
"Crayford Way is closed between Thames Road and Mill Place whilst crews work to make the scene safe and people are urged to avoid the area due to heavy congestion.
"The fire was producing a lot of smoke in the local area, so we advised residents to keep their windows and doors closed.
"There are currently no reports of any injuries."
The Brigade's 999 Control Officers took 10 calls to the blaze.
The Brigade was called at 1724 and the fire was under control by 1949. Fire crews from Plumstead, Deptford, Eltham, Lee Green and surrounding fire stations attended the scene.
The cause of the fire is under investigation.
Source: LFB